St. Joseph, straddling Missouri and Kansas, offers several quality hotel options. The Stoney Creek Hotel St. Joseph stands out for its unique decor and comfortable accommodations. The Drury Inn & Suites St. Joseph is known for its excellent customer service and complimentary happy hour.

History buffs might appreciate the Holiday Inn Express & Suites St. Joseph, located near several museums. The Candlewood Suites St. Joseph is ideal for extended stays, offering suite-style rooms with kitchenettes. Budget travelers might consider the Comfort Suites St. Joseph, which provides good value and amenities.